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. 2026 Jul 7;16:499. doi: 10.1038/s41398-026-04245-6

Table 2.

Association of static omega sign with potential predictors among MDD subjects.

Variables Static omega sign
No (174) Yes (56) Analysis
% % X2 Cramer’s V P
Male 28.7 46.4 5.99 0.16 0.01*
Marital status
Married/Cohabitating 40.4 39.1 0.02 0.01 0.88
Employment status, yes 53.8 41.3 2.18 0.11 0.14
Education
Tertiary level or above 38.8 23.9 0.02 0.13 0.07
Family income monthly < 15,000 HKD 37.2 31.8 0.42 0.05 0.52
Smoking, occasionally or often 11.2 7.0 / 0.06 0.57
Alcohol use, occasionally or often 15.9 4.7 3.62 0.14 0.06
Number of major depressive episodes ≥ 2 48.6 47.5 0.02 0.01 0.90
Anxious depression 20.7 26.8 0.91 0.06 0.34
Psychotropic
Antidepressants 66.3 79.2 3.20 0.12 0.07
Anxiolytics 30.2 26.4 0.28 0.04 0.60
Antipsychotics 20.1 26.4 0.94 0.07 0.33
Mood stabilizer 5.3 7.5 / 0.04 0.52
Polypharmacy (≥ 2 psychotropics) 36.7 39.6 0.15 0.03 0.70
Comorbidity
Panic disorder (lifetime) 10.1 6.3 / 0.06 0.58
Agoraphobia (current) 5.3 4.2 / 0.02 1.00
Social phobia (current) 5.9 4.2 / 0.03 1.00
OCD (current) 2.4 0 / 0.07 0.58
GAD (current) 7.1 20.8 / 0.19 0.01*
Psychotic features (lifetime) 8.9 16.7 2.40 0.11 0.12
PTSD (current) 0.6 4.2 / 0.13 0.12
Mean (SD) Mean (SD) Z r P
Age, y 49.5 (11.3) 57.9 (6.9) −5.29 −0.35 < 0.001***
HAMD-17 score 9.0 (6.4) 10.5 (7.4) −1.21 −0.08 0.23
Duration of illness, y 14.4 (10.9) 14.8 (11.0) −0.23 −0.02 0.82

OCD obsessive-compulsive disorder, GAD generalized anxiety disorder, PTSD post-traumatic stress disorder. Comparisons were conducted by using Mann-Whitney U test, Chi-square test, or Fisher’s exact test where applicable. r = The Rank-Biserial Correlation Coefficient.

***P < 0.001, *P < 0.05.