Table 2.

Crude in-hospital mortality across chloride-bicarbonate joint phenotypes.

Phenotype	MIMIC-IV, n	MIMIC-IV deaths	MIMIC-IV mortality (%)	eICU, n	eICU deaths	eICU mortality (%)
Low chloride + low bicarbonate	1,330	473	35.56	1,510	405	26.82
Low chloride + normal bicarbonate	1,177	273	23.19	1,628	248	15.23
Low chloride + high bicarbonate	1,021	203	19.88	2,416	330	13.66
Normal chloride + low bicarbonate	5,032	1,190	23.65	5,790	1,238	21.38
Normal chloride + normal bicarbonate	6,203	710	11.45	7,961	897	11.27
Normal chloride + high bicarbonate	2,203	266	12.07	5,617	624	11.11
High chloride + low bicarbonate	4,303	759	17.64	6,602	1,355	20.52
High chloride + normal bicarbonate	4,113	291	7.08	4,408	494	11.21
High chloride + high bicarbonate	460	51	11.09	1,113	150	13.48

Chloride categories: low <98 mmol/L, normal 98–107 mmol/L, and high >107 mmol/L. Bicarbonate categories: low <22 mmol/L, normal 22–26 mmol/L, and high >26 mmol/L.

eICU, eICU Collaborative Research Database; MIMIC-IV, Medical Information Mart for Intensive Care IV.