TABLE 1.
Phenotypes observed upon infection with γHV68Δ9743
| γHV68Δ9743 phenotype | Tissue | Time: (days) p.i. | Route of infection | Candidate genea |
|---|---|---|---|---|
| Reactivation, 5× increase | Peritoneal cells | 42 | i.p. | M1 (M1Δ511) (ref. 11) |
| Acute-phase titer, 10× decrease | Spleen | 9 | i.p. | M2 (M2.Stop) (ref. 19) |
| Latent load and reactivation, 24× and >13× decreases | Spleen | 17 | i.n. | M2 (M2.Stop) (ref. 19) |
| Acute-phase titer, 10× decrease | Lung | 6 | i.n. | ? |
| Latent load, 15× decrease | Spleen | 42 | i.n. | ? |
| Reactivation, >12× increase | Peritoneal cells | 42 | i.n. | M1?b |
a
Candidate genes are based on specific gene mutations that have given similar phenotypes. ref., reference.
b
While M1 mutants exhibit increased reactivation from latency in peritoneal cells following i.p. infection (11), it is unknown whether these viruses show increased reactivation following i.n. infection.