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. Author manuscript; available in PMC: 2026 Oct 1.
Published in final edited form as: Am J Respir Crit Care Med. 2026 Apr 1;212(4):768–777. doi: 10.1093/ajrccm/aamag006

Figure 1.

Figure 1

Mean standardized biomarker values stratified by endotype in discovery (solid lines) and validation (dotted lines) cohorts. Abbreviations: AREG, Amphiregulin; CEACAM6, carcinoembryonic antigen-related cell adhesion molecule 6; CHAD, Chondroadherin; CLEC3B, tetranectin; GDF15, growth/differentiation factor 15; IL1RL1, interleukin-1 receptor-like 1; LTBP2, latent-transforming growth factor beta-binding protein 2; MAMDC2, MAM domain-containing protein 2; MRC1, Macrophage Mannose Receptor 1; MSTN, growth/differentiation factor 8; OSMR, Oncostatin-M-specific receptor subunit beta; PPL, periplakin; RBFOX3, RNA binding protein fox-1 homolog 3; SDC1, Syndecan-1; SERPINA3, alpha-1-antichymotrypsin; SFTPA1, pulmonary surfactant-associated protein A1; SIGLEC8, sialic acid-binding Ig-like lectin 8; TFF2, Trefoil factor 2; TGFBR1, TGF-beta receptor type-1; THBS2, thrombospondin-2.