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. 2002 Jul;76(13):6689–6700. doi: 10.1128/JVI.76.13.6689-6700.2002

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Copyright © 2002, American Society for Microbiology

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FIG. 6. — HIV-1 virions enter BMVECs through a surface crater. BMVECs were exposed to HIV-1 at a multiplicity of 10⁵ RNA copies per cell, fixed at the indicated times, and examined by TEM. (A) At 3 h p.i., exuberant microvilli trap virions on the cell surface and in a large surface crater (asterisk). (Magnification, ×5,670.) (B) A higher magnification of panel A shows numerous virions (arrowheads) in a large surface crater (asterisk). A portion of the crater is clathrin coated (arrow). (Magnification, ×36,000.) (C) An occasional viral particle enters a clathrin-coated pit (arrow). (Magnification, ×60,000.)

FIG. 6. — HIV-1 virions enter BMVECs through a surface crater. BMVECs were exposed to HIV-1 at a multiplicity of 10⁵ RNA copies per cell, fixed at the indicated times, and examined by TEM. (A) At 3 h p.i., exuberant microvilli trap virions on the cell surface and in a large surface crater (asterisk). (Magnification, ×5,670.) (B) A higher magnification of panel A shows numerous virions (arrowheads) in a large surface crater (asterisk). A portion of the crater is clathrin coated (arrow). (Magnification, ×36,000.) (C) An occasional viral particle enters a clathrin-coated pit (arrow). (Magnification, ×60,000.)