TABLE 1.

Exposure of BMVEC to HIV-1 does not increase permeability in the BBB model^a

Virus exposure	Permeability coefficient (cm/min)b
	4 h p.i.c	24 h p.i.d	48 h p.i.e
No	0.000194, 0.000244	0.000326, 0.000264	0.000178, 0.000186
Yes	0.000234, 0.000275	0.000298, 0.000295	0.000186, 0.000193

^aDuplicate BBB models were either exposed in the upper chamber to HIV-1_LAI (1 million RNA copies) or left uninfected. At the indicated times, [¹⁴C]inulin (20 μl; 25,000 to 30,000 cpm) was added for 1 h, and the permeability coefficient was determined as described in Materials and Methods.

^bValues for duplicate experiments are shown.

^cMean difference, 0.00004; standard error of the difference, 0.00006; P = 0.5982.

^dMean difference, 0.00000; standard error of the difference, 0.00006; P = 0.9820.

^eMean difference, 0.00001; standard error of the difference, 0.00006; P = 0.9103.