FIG. 1.

Northern blot analysis of the GCs associated or unassociated with EBV. Total RNA extracted from the GC strains in SCID or nude mice (a) and from GC cell lines (b) was subjected to Northern blot analysis using IL-1β and glyceraldehyde 3-phosphate dehydrogenase cDNA probes. Expression of IL-1β was observed only in the KT tumor, a transplantable strain of EBVaGC; the level of expression was high. On the other hand, there was no expression in other strains or in seven GC cell lines, all of which are EBV negative. Normal gastric mucosa does not show any messaging of IL-1β.