TABLE 4.
Substitutions and deletions in the amino acid sequence of LMP-1 identified in EBV strains infecting donor cells or derived cell lines
| Nucleotide position | B95-8 sequence
|
Mutationa in PBL25 | ||
|---|---|---|---|---|
| Codon | Nucleotide or change | Amino acid | ||
| 5′ region | ||||
| 169183 | 46 | G | Asp | A/Asn |
| 169003 | 106 | T | Phe | A/Ile |
| 168943 | 126 | A | Leu | C/Phe |
| 168934 | 129 | G | Met | T/Ile |
| 168934 | 132 | A | Arg | G/Gly |
| 168889 | 144 | T | Phe | A/Ile |
| 168871 | 150 | A | Asp | C/Ala |
| 168868 | 151 | A | Leu | C/Ile |
| 3′ region | ||||
| 168754 | 189 | A | Gln | C/Pro |
| 168265-168294 | 352-343 | 30-bp deletion | NAb | Deletion |
a
Comparison is to the B95-8 reference strain (GenBank accession no. X66863). The mutated nucleotide and corresponding amino acid are shown. No mutations in cell lines B-EBVneo, NC5, TC, E1, and TE1 were found.
b
NA, not applicable.