Table 1.

Overall gene-level architecture (shared vs. differential)

Metric	Value	P-value
Pearson r (Stouffer-Z, all 13,580 genes)	+ 0.6764	0.00e + 00
Spearman ρ (Stouffer-Z)	+ 0.7725	0.00e + 00
Direction concordance (nominal sig genes)	99.9% (1,406/1,408)	0.00e + 00
RRHO peak enrichment	2.16× (top-2,000 genes)	—
Differential genes (FDR < 0.05)	82	—

Significant overlap (Fisher’s exact):

• Nominal P<0.05: 1,408 genes (OR=2.78, P=3.79e-124)

• FDR<0.05: 590 genes (OR=3.55, P=1.65e-97)

• Bonferroni: 66 genes (OR=9.59, P=2.16e-36)

• Top-500: 92 genes (5.00× enrichment, P=1.59e-39)