Table 2.

Pathway enrichment comparison (Early Dx / childhood vs. late Dx)

Gene Set	Early Dx Enrich. (MW-P)	Late Dx Enrich. (MW-P)	Δ (Late stronger)	Notes
KEGG_Long_Term_Potentiation	1.10 × (0.035)	1.34 × (1.4e-8)	+ 0.24×	Synaptic plasticity
REACTOME_Complement_Cascade	1.09× (NS)	1.22 × (5.1e-5)	+ 0.13×	Immune/inflammation
GOBP_Synaptic_Transmission_Glutamatergic	0.80× (NS)	1.01× (NS)	+ 0.21×	Glutamate signaling
Adult_Microglia_Markers	1.13 × (0.052)	0.73× (NS)	–0.40×	Neurodev./autism-like
HGNC_Histocompatibility_Complex	1.12 × (0.096)	0.65× (NS)	–0.47×	MHC/immune
Housekeeping / Monoamines / others	~ 1.0× (NS)	~ 1.0× (NS)	—	No difference

Bold values indicate statistical significance or near-significance driving the interpretation. NS = Not significant. P-values in Tables 2, 3 and 4are nominal unless otherwise stated. Across 26 gene-set tests, a simple Bonferroni threshold is approximately 0.0019; the late-diagnosed long-term potentiation and complement cascade signals exceed this threshold, whereas the childhood microglia and MHC signals are suggestive only