Table 3.
Early Dx (childhood) — multi-gene-set TWAS summary
| Gene Set | Tested | Nominal sig | FDR sig | Enrich Ratio | MW P |
|---|---|---|---|---|---|
| Adult_Microglia_Markers | 19 | 5 | 0 | 1.13× | 5.19e-02 |
| HGNC_Histocompatibility_Complex | 15 | 2 | 0 | 1.12× | 9.61e-02 |
| GOBP_Synapse_Pruning | 14 | 1 | 0 | 1.11× | 6.36e-02 |
| KEGG_Long_Term_Potentiation | 47 | 7 | 0 | 1.10× | 3.47e-02 |
| REACTOME_Complement_Cascade | 29 | 4 | 0 | 1.09× | 3.22e-01 |
| Housekeeping | 123 | 24 | 0 | 1.00× | 8.63e-01 |
| Monoamines | 60 | 8 | 0 | 0.99× | 5.96e-01 |
| GOBP_Regulation_of_Synaptic_Plasticity | 137 | 18 | 0 | 1.01× | 2.42e-01 |
| GOBP_Synaptic_Transmission_Glutamatergic | 66 | 7 | 0 | 0.80× | 1.00e + 00 |