Table 2.
Laboratory parameters and ferroptosis-related markers in patients with and without myocardial injury (n = 180)
| Laboratoryresults | SIMI(N = 91) | No-SIMI(N = 89) | p | Total(N = 180) |
|---|---|---|---|---|
| MDA (nmol/ml) | 6.08(5.38–6.67) | 4.47(3.92–5.30) | < 0.001*** | 5.38(4.29–6.37) |
| LPO (ng/ml) | 26.14(23.18–28.62) | 19.15(16.14–23.01) | < 0.001*** | 23.09(17.69–27.28) |
| GSH (ng/ml) | 5.26(4.75–5.75) | 6.79(6.04–7.82) | < 0.001*** | 5.89(4.97–7.16) |
| ROS (IU/ml) | 633.23(553.86-708.18) | 500.95(450.24-542.84) | < 0.001*** | 553.37(480.56-661.81) |
| Fe²⁺ (µmol/l) | 2.85(2.67–3.35) | 2.22(1.92–2.48) | < 0.001*** | 2.60(2.14–2.98) |
| PCT (ng/ml) | 6.00 (1.10, 39.11) | 2.02 (0.69, 7.43) | 0.006** | 3.12 (0.81, 19.18) |
| CRP (mg/L) | 151.60 (100.00, 224.90) | 154.40 (89.50, 227.00) | 0.923 | 152.75 (91.75, 224.95) |
| Endotoxin (Eu/ml) | 0.07 (0.03, 0.14) | 0.05 (0.03, 0.10) | 0.029* | 0.05 (0.03, 0.12) |
| IL-6 (pg/ml) | 220.80 (53.47, 1000.00) | 102.10 (29.09, 298.00) | 0.010* | 121.50 (40.05, 379.27) |
| cTNI (µg/l) | 0.14 (0.08, 0.68) | 0.02 (0.01, 0.03) | <0.001*** | 0.05 (0.02, 0.14) |
| BNP (pg/ml) | 295.00 (128.50, 644.00) | 75.00 (37.00, 133.00) | <0.001*** | 132.00 (58.53, 389.75) |
| TNF-α (pg/ml) | 19.70 (13.80, 33.10) | 17.80 (12.40, 29.00) | 0.235 | 19.45 (13.35, 30.80) |
| LVEF (%) | 43.81 ± 3.27 | 57.76 ± 3.71 | <0.001*** | 50.71 ± 7.81 |
| LVEF ≥ 50 (%) | 1.1 | 100.0 | <0.001*** | 50.0 |
| LVEF<50 (%) | 98.9 | 0.0 | <0.001*** | 50.0 |
| SBP (mmHg) | 116.20 ± 21.71 | 116.89 ± 20.60 | 0.827 | 116.54 ± 21.11 |
| DBP (mmHg) | 67.02 ± 12.92 | 66.73 ± 13.65 | 0.883 | 66.88 ± 13.25 |
| MAP (mmHg) | 84.30 (74.70, 92.00) | 83.70 (78.30, 92.00) | 0.736 | 84.30 (75.60, 92.08) |
| CO (L/min) | 8.04 (7.05, 8.51) | 8.42 (7.18, 9.49) | 0.022* | 8.33 (7.15, 9.10) |
| CI (L/min/m²) | 4.28 (4.00, 5.16) | 4.86 (4.26, 5.54) | 0.005** | 4.53 (4.03, 5.44) |
| P (bpm) | 100.00 (86.00, 116.00) | 100.00 (86.75, 112.50) | 0.708 | 100.00 (86.00, 115.75) |
Note: ROS, reactive oxygen species; MDA, malonaldehyde༛LPO, lipid peroxidation༛GSH, glutathione ༛PCT, Procalcitonin; CRP, C-reactive protein; IL-6, Interleukin-6;cTNI, Cardiac troponin I; BNP, B-type natriuretic peptide; TNF-α,Tumor necrosis factor-alpha; LVEF, Left ventricular ejection fraction, SBP, Systolic Blood Pressure; DBP, Diastolic Blood Pressure; MAP, Mean Arterial Pressure; CO, Cardiac Output; CI, Cardiac Index; *p<0.05, **p<0.01, ***p<0.001༛For normally distributed data, the mean ± standard deviation is used, and for non-normal distribution, the median, lower quartile and upper quartile are used