Table 4.
Diagnostic performance of biomarkers for SIMI
| Marker | AUC (95% CI) | Cutoff | Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|---|---|
| MDA(nmol/ml) | 0.787 (0.667–0.906) | 5.364 | 0.780 | 0.753 | 0.763 | 0.770 |
| LPO(ng/ml) | 0.746 (0.619–0.873) | 23.041 | 0.769 | 0.764 | 0.769 | 0.764 |
| GSH(ng/ml) | 0.757(0.632–0.882) | 5.9668 | 0.802 | 0.775 | 0.785 | 0.793 |
| ROS(IU/ml) | 0.793 (0.674–0.911) | 551.656 | 0.780 | 0.764 | 0.772 | 0.773 |
| Fe2+(µmol/l) | 0.825 (0.714–0.936) | 2.543 | 0.835 | 0.820 | 0.826 | 0.830 |
| cTnI(µg/l) | 0.992 (0.966-1.000) | 0.050 | 1.000 | 0.989 | 0.989 | 1.000 |
| BNP(pg/ml) | 0.774 (0.651–0.896) | 126.000 | 0.769 | 0.730 | 0.745 | 0.756 |
| APACHEII | 0.591 (0.448–0.735) | 23.000 | 0.286 | 0.910 | 0.765 | 0.555 |
| SOFA | 0.649 (0.510–0.789) | 8.000 | 0.440 | 0.809 | 0.702 | 0.585 |
ROS, reactive oxygen species; DA, malonaldehyde; LPO, lipid peroxidation; GSH, glutathione; cTNI, Cardiac troponin I; BNP, B-type natriuretic peptide; SIMI: Sepsis-Induced Myocardial Injury.ApacheII: Acute Physiology and Chronic Health Evaluation II; SOFA: Sequential Organ Failure Assessment