Table 2.
Therapeutic evaluation according to AML subtype with KIT mutation in TARGET
| With AML1::ETO and KIT mutation | Without AML1::ETO but with KIT mutation | P value | |
|---|---|---|---|
| Course 1 | |||
| Bone marrow | 0.35 | ||
| CR | 78.6% (22/28) | 90.6% (29/32) | |
| Not CR | 21.4% (6/28) | 9.4% (3/32) | |
| MRD | 0.05 | ||
| Yes | 30.0% (6/20) | 4.0% (1/25) | |
| No | 70.0% (14/20) | 96.0% (24/25) | |
| Course 2 | |||
| Bone marrow | 0.48 | ||
| CR | 96.4% (27/28) | 100.0% (31/31) | |
| Not CR | 3.6% (1/28) | 0.0% (0/31) | |
| MRD | 0.44 | ||
| Yes | 5.0% (1/20) | 0.0% (0/25) | |
| No | 95.0% (19/20) | 100.0% (25/25) | |
P values were analyzed by the Chi-Square Test, compared with AML1::ETO and KIT mutation group
CR Complete remission, MRD Minimal residual disease