Table 3.
Therapeutic evaluation according to KIT mutation with AML1::ETO in TARGET
| AML1::ETO with KIT mutation | AML1::ETO without KIT mutation | P value | |
|---|---|---|---|
| Course 1 | |||
| Bone marrow | 0.81 | ||
| CR | 78.6% (22/28) | 80.6% (79/98) | |
| Not CR | 21.4% (6/28) | 19.4% (19/98) | |
| MRD | 0.48 | ||
| Yes | 30.0% (6/20) | 19.4% (14/72) | |
| No | 70.0% (14/20) | 80.6% (58/72) | |
| Course 2 | |||
| Bone marrow | 0.95 | ||
| CR | 96.4% (27/28) | 93.8% (91/97) | |
| Not CR | 3.6% (1/28) | 6.2% (6/97) | |
| MRD | 0.77 | ||
| Yes | 5.0% (1/20) | 10.4% (7/67) | |
| No | 95.0% (19/20) | 89.6% (60/67) | |
P values were analyzed by the Chi-Square Test, compared with AML1::ETO and KIT mutation group
CR Complete remission, MRD Minimal residual disease