Table 2. Treatment protocol.

Treatment element/drug	Single or daily dose	Days of application per element
CET
Cytarabine (1-hour IV)	100 mg/m2 per day	1–7
Etoposide (2-hour IV)	150 mg/m2 per day	3–5
Pirarubicin (1-hour IV)	25 mg/m2 per day	1, 2
AZA-CET
Azacitidine (10-minute IV)	75 mg/m2 per day*	1–5
Cytarabine (1-hour IV)	100 mg/m2 per day	6–12
Etoposide (2-hour IV)	150 mg/m2 per day	8–10
Pirarubicin (1-hour IV)	25 mg/m2 per day	6, 7
CT
Cytarabine (1-hour IV)	100 mg/m2 per day	1–7
Pirarubicin (1-hour IV)	25 mg/m2 per day	1, 2
AZA-CT
Azacitidine (10-minute IV)	75 mg/m2 per day*	1–5
Cytarabine (1-hour IV)	100 mg/m2 per day	6–12
Pirarubicin (1-hour IV)	25 mg/m2 per day	6, 7
AZA-cCVT
Azacitidine (10-minute IV)	75 mg/m2 per day*	1–5
Cytarabine (24-hour continuous IV)	100 mg/m2 per day	6–12
Vincristine (IV push)	1 mg/m2 per day†	7
Pirarubicin (1-hour IV)	40 mg/m2 per day	6
AZA-hCE
Azacitidine (10-minute IV)	75 mg/m2 per day*	1–5
Cytarabine (2-hour IV)	1 g/m2 per dose	6–10 (every 12 hours)
Etoposide (2-hour IV)	100 mg/m2 per day	7–9

^*The dose of azacitidine is 2.5 mg/kg per day in patients weighing <10 kg or <1 year of age.

^†Max dose is 1 mg/body per day.

AZA, azacitidine; AZA-cCVT, azacitidine + continuous cytarabine + vincristine + pirarubicin; AZA-CT, azacitidine + cytarabine + pirarubicin; AZA-hCE, azacitidine + high-dose cytarabine + etoposide; CET, cytarabine + etoposide + pirarubicin; CT, cytarabine + pirarubicin; IV, intravenous.