Table 1.
IHD-related mortality among US adults (aged ≥25 years) (1999–2023): deaths, AAMR, and APC.
| Variable | Deaths (n) | Overall AAMR (95% CI) | Trend segment | Year interval | APC (95% CI) | AAPC (95% CI) |
|---|---|---|---|---|---|---|
| Overall | 10,200,362 | 185.22 (184.65–185.79) | 1 | 1999–2002 | ‒3.81 (−5.13 to −2.48)*** | ‒3.51 (−3.99 to −3.03)*** |
| 2 | 2002–2010 | ‒5.29 (−5.67 to −4.91)*** | ||||
| 3 | 2010–2018 | ‒2.77 (−3.20 to −2.35)*** | ||||
| 4 | 2018–2021 | 1.12 (−2.14 to 4.49) | ||||
| 5 | 2021–2023 | ‒5.59 (−8.68 to −2.39)** | ||||
| Sex | ||||||
| Female | 4,601,456 | 138.69 (137.82–139.56) | 1 | 1999–2002 | ‒3.75 (−5.19 to −2.30)*** | ‒4.04 (−4.61 to −3.47)*** |
| 2 | 2002–2010 | ‒5.86 (−6.29 to −5.44)*** | ||||
| 3 | 2010–2018 | ‒3.52 (−4.01 to −3.02)*** | ||||
| 4 | 2018–2021 | 0.67 (−3.22 to 4.71) | ||||
| 5 | 2021–2023 | ‒6.05 (−9.77 to −2.17)** | ||||
| Male | 5,598,906 | 245.58 (244.55–246.62) | 1 | 1999–2010 | ‒4.74 (−4.97 to −4.52)*** | ‒3.29 (−3.80 to −2.77)*** |
| 2 | 2010–2018 | ‒2.46 (−2.94 to −1.97)*** | ||||
| 3 | 2018–2021 | 1.37 (−2.25 to 5.12) | ||||
| 4 | 2021–2023 | ‒5.32 (−8.73 to −1.78)** | ||||
| Race | ||||||
| Hispanic | 563,283 | 141.90 (139.97–143.83) | 1 | 1999–2014 | ‒5.31 (−5.73 to −4.89)*** | ‒4.13 (−4.97 to −3.29)*** |
| 2 | 2014–2021 | ‒0.64 (−2.21 to 0.95) | ||||
| 3 | 2021–2023 | ‒7.21 (−15.38 to 1.76) | ||||
| NH Black | 1,078,856 | 217.58 (215.49–219.68) | 1 | 1999–2002 | ‒2.53 (−3.71 to −1.32)*** | ‒3.51 (−3.91 to −3.10)*** |
| 2 | 2002–2011 | ‒5.49 (−5.77 to −5.21)*** | ||||
| 3 | 2011–2018 | ‒2.71 (−3.18 to −2.25)*** | ||||
| 4 | 2018–2021 | 2.66 (−0.07 to 5.45) | ||||
| 5 | 2021–2023 | ‒7.59 (−10.09 to −5.01)*** | ||||
| NH White | 8,260,439 | 190.10 (189.45–190.75) | 1 | 1999–2010 | ‒4.87 (−5.11 to −4.62)*** | ‒3.40 (−4.02 to −2.77)*** |
| 2 | 2010–2018 | ‒2.69 (−3.25 to −2.12)*** | ||||
| 3 | 2018–2021 | 1.18 (−3.20 to 5.76) | ||||
| 4 | 2021–2023 | ‒4.75 (−8.96 to −0.36)* | ||||
| NH Other | 263,867 | 109.60 (107.43–111.78) | 1 | 1999–2015 | ‒4.47 (−4.74 to −4.20)*** | ‒3.74 (−4.30 to −3.19)*** |
| 2 | 2015–2021 | ‒0.63 (−2.00 to 0.77) | ||||
| 3 | 2021–2023 | ‒7.05 (−12.21 to −1.58)* | ||||
| Urban/rural | ||||||
| Metropolitan | 7,342,045 | 189.07 (188.43–189.71) | 1 | 1999–2002 | ‒3.82 (−5.11 to −2.52)*** | ‒3.69 (−4.06 to −3.33)*** |
| 2 | 2002–2010 | ‒5.51 (−5.89 to −5.14)*** | ||||
| 3 | 2010–2018 | ‒2.93 (−3.34 to −2.51)*** | ||||
| 4 | 2018–2020 | 0.90 (−2.29 to 4.20) | ||||
| Non-metropolitan | 1,762,306 | 212.60 (211.12–214.08) | 1 | 1999–2010 | ‒4.26 (−4.55 to −3.98)*** | ‒3.06 (−3.28 to −2.84)*** |
| 2 | 2010–2020 | ‒1.72 (−2.10 to −1.34)*** | ||||
| Region | ||||||
| Northeast | 2,177,581 | 198.64 (197.32–199.96) | 1 | 1999–2002 | ‒3.56 (−5.06 to −2.03)*** | ‒3.86 (−4.42 to −3.29)*** |
| 2 | 2002–2011 | ‒5.19 (−5.56 to −4.83)*** | ||||
| 3 | 2011–2017 | ‒2.98 (−3.83 to −2.11)*** | ||||
| 4 | 2017–2020 | ‒0.10 (−4.06 to 4.03) | ||||
| 5 | 2020–2023 | ‒5.53 (−7.50 to −3.51)*** | ||||
| Midwest | 2,339,054 | 188.17 (186.96–189.38) | 1 | 1999–2009 | ‒4.92 (−5.16 to −4.69)*** | ‒3.35 (−3.87 to −2.83)*** |
| 2 | 2009–2018 | ‒2.78 (−3.16 to −2.39)*** | ||||
| 3 | 2018–2021 | 1.41 (−2.26 to 5.22) | ||||
| 4 | 2021–2023 | ‒4.95 (−8.44 to −1.31)* | ||||
| South | 3,736,179 | 187.21 (186.26–188.17) | 1 | 1999–2002 | ‒3.30 (−4.81 to −1.76)*** | ‒3.40 (−3.93 to −2.87)*** |
| 2 | 2002–2009 | ‒5.68 (−6.23 to −5.14)*** | ||||
| 3 | 2009–2018 | ‒2.84 (−3.23 to −2.45)*** | ||||
| 4 | 2018–2021 | 1.84 (−1.78 to 5.60) | ||||
| 5 | 2021–2023 | ‒5.62 (−8.99 to −2.13)** | ||||
| West | 1,947,548 | 165.49 (164.33–166.66) | 1 | 1999–2013 | ‒4.93 (−5.23 to −4.63)*** | ‒3.46 (−3.73 to −3.18)*** |
| 2 | 2013–2023 | ‒1.35 (−1.9 to −0.8)*** | ||||
NH, not Hispanic; AAPC, average annual percentage change.
*p < 0.05; **p < 0.01; ***p < 0.001.