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. 2026 Sep 18;13:1883973. doi: 10.3389/fcvm.2026.1883973

Table 2.

Pairwise tests of parallelism for ischemic heart disease mortality trends by demographic and geographic subgroups.

Comparison K max Numerator df Denominator df Permutations p-value Result
Sex (1999–2023)
Female vs. male 4 9 30 4,500 *** Rejected
Race/ethnicity (1999–2023)
Hispanic vs. NH Black 4 9 30 4,500 ** Rejected
Hispanic vs. NH Other 2 5 38 4,500 ** Rejected
Hispanic vs. NH White 4 9 30 4,500 *** Rejected
NH Black vs. NH Other 4 9 30 4,500 ** Rejected
NH Black vs. NH White 4 9 30 4,500 * Rejected
NH Other vs. NH White 4 9 30 4,500 0.3964 Failed to reject
Census region (1999–2023)
Midwest vs. Northeast 4 9 30 4,500 *** Rejected
Midwest vs. South 4 9 30 4,500 *** Rejected
Midwest vs. West 4 9 30 4,500 *** Rejected
Northeast vs. South 4 9 30 4,500 ** Rejected
Northeast vs. West 4 9 30 4,500 * Rejected
South vs. West 4 9 30 4,500 ** Rejected
Urbanization (1999–2020)
Metropolitan vs. Non-metropolitan 3 7 28 4,500 *** Rejected

NH, not Hispanic; Kmax, assumed number of joinpoints for the comparison test; df, degrees of freedom. The maximum number of joinpoints (Kmax) for each pairwise test was determined based on the WBIC-optimal model of each subgroup, leading to varied Kmax across comparisons. This software-driven setting should be considered when interpreting pairwise parallelism outputs due to differing joinpoint specifications between contrasts. Urbanization analysis limited to 1999–2020.

*p < 0.05; **p < 0.01; ***p < 0.001 by test of parallelism (4,500 permutations).