Table 3.

IHD-related mortality among US adults (aged ≥25 years) (1999–2023): deaths, CMR, and APC.

Age	Deaths (n)	Overall CMR (95% CI)	Trend segment	Year interval	APC (95% CI)	AAPC (95% CI)
25–34 years	25,015	2.37 (2.22–2.51)	1	1999–2003	2.63 (−1.14 to 12.24)	‒0.89 (−1.63 to −0.24)*
			2	2003–2023	‒1.58 (−4.84 to −1.16)*
35–44 years	145,451	13.69 (13.34–14.04)	1	1999–2003	0.20 (−0.89 to 2.07)	‒1.97 (−2.20 to −1.78)***
			2	2003–2009	‒3.75 (−5.32 to −3.06)***
			3	2009–2018	‒2.31 (−2.91 to −1.23)**
			4	2018–2021	3.86 (1.76 to 5.13)***
			5	2021–2023	‒7.63 (−10.46 to −4.69)***
45–54 years	546,327	52.07 (51.38–52.76)	1	1999–2018	‒2.36 (−2.52 to −2.24)***	‒2.19 (−2.38 to −2.06)***
			2	2018–2021	1.97 (0.13 to 2.95)*
			3	2021–2023	‒6.50 (−8.93 to −3.67)***
55–64 years	1,203,237	134.72 (133.51–135.92)	1	1999–2009	‒4.54 (−4.94 to −4.24)***	‒2.48 (−2.63 to −2.36)***
			2	2009–2018	‒1.01 (−1.65 to −0.61)***
			3	2018–2021	2.55 (0.93 to 3.53)**
			4	2021–2023	‒5.91 (−7.86 to −3.70)***
65–74 years	1,845,522	301.26 (299.09–303.43)	1	1999–2010	‒5.97 (−6.51 to −5.62)***	‒3.52 (−3.72 to −3.37)***
			2	2010–2018	‒1.65 (−5.30 to −1.01)**
			3	2018–2021	1.77 (−1.50 to 2.96)
			4	2021–2023	‒5.00 (−7.51 to −1.11)***
75–84 years	2,828,224	806.68 (802.01–811.35)	1	1999–2002	‒4.18 (−4.99 to −2.78)***	‒4.04 (−4.16 to −3.94)***
			2	2002–2010	‒5.75 (−6.48 to −5.51)***
			3	2010–2018	‒3.39 (−3.88 to −2.99)***
			4	2018–2021	0.55 (−0.67 to 1.35)
			5	2021–2023	‒6.19 (−7.70 to −4.62)***
85+ years	3,606,586	2,610.24 (2,596.80–2,623.68)	1	1999–2014	‒4.75 (−5.09 to −4.49)***	‒3.73 (−3.92 to −3.56)***
			2	2014–2023	‒2.00 (−2.67 to −1.10)**

AAPC, average annual percentage change.

*p < 0.05; **p < 0.01; ***p < 0.001.