PICO question 5
In adults with (progressive) CLAD, should anti-thymocyte globulin be used?

Recommendation
• In adults with (progressive) CLAD, we suggest either using anti-thymocyte globulin or not using it. (Conditional recommendation for either the intervention or the comparison, very low certainty of evidence)

Remarks
We suggest using ATG with caution in patients with a history of or risk for malignancy (e.g., recent malignancy, malignancy with a high risk of recurrence, Epstein-Barr virus (EBV) mismatch), or a history of infections (especially difficult-to-treat or fungal infections)