PICO question 6
In adults with (progressive) CLAD, should alemtuzumab be used?

Recommendation
• In adults with (progressive) CLAD, we suggest either using alemtuzumab or not using it. (Conditional recommendation for either the intervention or the comparison, very low certainty of evidence)

Remarks
Alemtuzumab should be used with caution in patients with a history of or risk for malignancy (e.g., recent cancer, malignancy with a high risk of recurrence, EBV mismatch) or a history of infections, particularly difficult-to-treat or fungal infections