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. 2026 Sep 18;39:16959. doi: 10.3389/ti.2026.16959
PICO question 8
In adults with (progressive) CLAD, should montelukast be used?
Recommendation
• In adults with (progressive) CLAD, we suggest either using montelukast or not using it. (Conditional recommendation for either the intervention or the comparison, low certainty of evidence)
Remarks
Montelukast may be effective in cases of early BOS. In patients with new-onset BOS stage 1, a trial of montelukast can be considered