Table 3.

Postoperative laboratory parameters and composite indices according to wound complication status

Variable	Total (n = 86)	No complication (n = 62)	Complication (n = 24)	p-value
CRP (mg/L)
POD1	86 [62–118]	78 [55–102]	112 [85–146]	< 0.001
POD3	122 [88–162]	104 [76–138]	168 [132–210]	< 0.001
ΔCRP	31 [12–57]	24 [8–44]	52 [28–81]	< 0.001
Albumin (g/dL)
POD1	3.4 ± 0.5	3.5 ± 0.5	3.1 ± 0.4	0.002
POD3	3.1 ± 0.4	3.3 ± 0.4	2.8 ± 0.3	< 0.001
ΔAlbumin	−0.3 ± 0.3	−0.2 ± 0.3	−0.4 ± 0.3	0.004
Neutrophil count (×10⁹/L)
POD1	7.4 [6.0–9.1]	7.1 [5.8–8.6]	8.2 [6.7–9.9]	0.061
POD3	8.3 [6.7–10.2]	7.6 [6.1–9.2]	9.8 [8.2–11.6]	0.001
Lymphocyte count (×10⁹/L)
POD1	1.3 [1.0–1.7]	1.4 [1.1–1.8]	1.1 [0.8–1.5]	0.028
POD3	1.2 [0.9–1.6]	1.4 [1.1–1.8]	0.9 [0.7–1.2]	< 0.001
NLR
POD1	4.9 [3.5–7.1]	4.3 [3.1–6.0]	6.8 [5.2–8.9]	0.002
POD3	6.9 [4.9–9.2]	5.6 [4.2–7.4]	10.5 [8.4–13.2]	< 0.001
ΔNLR	1.6 [0.5–3.3]	1.1 [0.2–2.1]	3.6 [2.0–5.5]	< 0.001
CAR
POD1	25.7 [17.8–37.4]	22.4 [15.9–30.8]	36.2 [26.5–48.9]	< 0.001
POD3	39.1 [27.3–57.8]	31.8 [23.1–42.6]	60.4 [46.8–78.9]	< 0.001
ΔCAR	10.9 [4.6–22.8]	8.3 [3.2–15.9]	23.1 [12.4–35.6]	< 0.001
WINA
POD1	132.8 [82.6–221.5]	96.7 [63.5–151.9]	244.6 [174.8–334.2]	< 0.001
POD3	281.4 [164.7–486.9]	178.5 [119.4–276.3]	628.7 [472.9–803.6]	< 0.001
ΔWINA	132.4 [57.1–278.6]	78.6 [36.9–146.8]	352.8 [236.4–486.7]	< 0.001

Values are presented as mean ± standard deviation or median [interquartile range]. CAR and WINA were calculated separately for each patient before the summary statistics were generated. Continuous variables were compared using the independent-samples t-test, Welch’s t-test, or Mann–Whitney U test, as appropriate. Delta values were calculated as the POD3 value minus the corresponding POD1 value. Abbreviations: CAR C-reactive protein-to-albumin ratio, CRP C-reactive protein, NLR neutrophil-to-lymphocyte ratio, POD postoperative day, WINA Wound Inflammation–Nutrition Index