TABLE 1.
Demyelination and virus titers in adoptive transfer recipients
| Enrichment group | Time | % Demyelination (no.) | No. of samples with detectable virus/total no. | Titer (log10 PFU/g of tissue ± SE) |
|---|---|---|---|---|
| Virus only | Days 10 to 13 p.i. | N/Ad | 6/6 | 6.00 ± 0.13a |
| Undepleted cells | Days 11 to 13 p.i.; day 7 to 9 p.t. | |||
| B6 | 15.6 ± 2.0 (9) | 3/5 | 3.04 ± 0.44b | |
| IFN-γ−/− | 17.7 ± 2.1 (7) | 4/4 | 4.77 ± 0.08 | |
| CD4 T cells | Day 10 or 11 p.i.; day 6 or 7 p.t. | |||
| B6 | 8.0 ± 1.9 (4)c | 3/3 | 4.96 ± 0.23 | |
| IFN-γ−/− | 20.0 ± 3.0 (7) | 8/8 | 4.93 ± 0.12 |
a
Virus titers were significantly higher in the absence of adoptive transfer (P < 0.005).
b
Virus titers were significantly lower in recipients of undepleted B6 splenocytes than in members of all other groups (P < 0.02).
c
A significant difference was observed in amounts of demyelination between recipients of CD4 T-cell-enriched B6 and IFN-γ−/− populations (P < 0.05) as measured by Student's t test.
d
N/A, not available.