TABLE 3.
Macrophages microglia in gray and white matter of spinal cords
| Donor cella | No. in
|
||
|---|---|---|---|
| total spinal cord | gray matter | white matter | |
| B6 | 422 ± 60b | 209 ± 30b | 213 ± 38 |
| IFN-γ−/− | 213 ± 23 | 56 ± 8 | 158 ± 20 |
Each group consisted of three individual animals that received CD4 T-cell-enriched splenocytes from B6 or IFN-γ−/− mice. F4/80+ cells in 0.63-mm-wide cross-sections at eight levels within the spinal cords were counted.
A significant difference was observed in the numbers of F4/80+ cells in the total spinal cord and in gray matter between recipients of CD4 T-cell-enriched B6 and IFN-γ−/− populations (P < 0.002) as measured by Student's t test.