Figure 2.

Constitutive activity of ε subunit-containing receptors. The ε subunit-containing receptors display spontaneous currents that can be blocked with picrotoxin. A. A representative current trace recorded from an oocyte expressing spontaneously open α3β1ε receptors is shown. GABA (30 μM) application induced typical inward currents. Picrotoxin (Picro, 100 μM) reversibly blocked spontaneously active receptors as shown by blockade (outward current) of apparent leakage current. B. Peak amplitudes (in nA given as means ± standard errors) of GABA- and picrotoxin-induced currents in six oocytes expressing α3β1ε receptors.