Table 2.

Clinical pointers for DIRV

Clinical pointer	Possible DIRV	Treatment
“Fire and Ice” (Hemorrhage + Ischemia)	Vancomycin (HORV)	Stop drug; IVT Steroids; PPV.
Glistening perimacular spots	Talc / IV Drug Use	OCTA; Systemic workup for emboli.
Bilateral sheathing + Renal issues	PTU / Phenytoin	Order p-ANCA; Switch meds.
Hypopyon + Diffuse Venous Leakage	Rifabutin	Stop drug; Topical Steroids.

ANCA: Antineutrophil Cytoplasmic Antibodies, HORV: Hemorrhagic Occlusive Retinal Vasculitis, IVT: Intravitreal Therapy, OCTA: Optical Coherence Tomography Angiography, PPV: Pars Plana Vitrectomy, PTU: Propylthiouracil