Table 3.
Univariable and multivariable Cox proportional hazards regression analyses for overall survival.
| Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|
| Variable | HR | 95% CI | P-value | HR | 95% CI | P-value |
| Sex | ||||||
| Female | Reference | Reference | ||||
| Male | 0.62 | 0.32-1.20 | 0.152 | 0.78 | 0.37-1.66 | 0.518 |
| Age | 0.98 | 0.96-1.01 | 0.305 | 1.00 | 0.97-1.03 | 0.866 |
| Tprimary | ||||||
| 1 | Reference | |||||
| 2 | 0.75 | 0.30-1.84 | 0.526 | |||
| 3 | 1.26 | 0.61-2.60 | 0.529 | |||
| 4 | 2.13 | 0.75-6.08 | 0.157 | |||
| N | ||||||
| 0 | Reference | |||||
| 1 | 1.50 | 0.74-3.03 | 0.265 | |||
| Number of metastatic sites | ||||||
| 1 | Reference | |||||
| 2 | 1.31 | 0.68-2.53 | 0.423 | |||
| 3 | 2.13 | 0.50-9.12 | 0.306 | |||
| 4 | 1.45 | 0.20-10.8 | 0.717 | |||
| IMDC | ||||||
| Favorable | Reference | Reference | ||||
| Intermediate | 1.91 | 0.73-4.97 | 0.184 | 1.44 | 0.53-3.91 | 0.477 |
| Poor | 3.78 | 1.33-10.7 | 0.013 | 2.86 | 0.95-8.37 | 0.062 |
| IgG group | ||||||
| Normal IgG | Reference | Reference | ||||
| Elevated IgG | 3.09 | 1.68-5.67 | <0.001 | 2.55 | 1.30-5.00 | 0.006 |
Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards regression models. Variables included in the multivariable analysis were age, sex, IMDC risk group, and baseline serum IgG group.
CI, confidence interval; HR, hazard ratio; IMDC, International Metastatic Renal Cell Carcinoma Database Consortium; IgG, immunoglobulin G.