Table 2.
Endpoint definitions across included randomized controlled trials.
| Study | Myocardial Infarction | Target Lesion Revascularization (TLR) | Target Vessel Revascularization (TVR) | Independent Adjudication | Definition of Events |
|---|---|---|---|---|---|
| Cortese (8) | Peri-procedural and spontaneous | Clinically driven | Protocol-driven | Yes | MI: defined as a rise in cardiac biomarkers (CK-MB, troponin); TLR: revascularization driven by ischemic symptoms or positive stress testing; TVR: revascularization of the target vessel based on angiographic criteria. |
| Latib (9) | Peri-procedural and spontaneous | Clinically driven | Protocol-driven | Yes | MI: increase in CK-MB or troponin levels with associated symptoms; TLR: clinically driven by symptoms or evidence of ischemia; TVR: protocol-driven when restenosis was confirmed by angiography. |
| Sinaga (10) | Peri-procedural and spontaneous | Clinically driven | Protocol-driven | Yes | MI: defined by elevation of troponin or CK-MB with chest pain; TLR: clinically driven based on angiographic or symptomatic indications; TVR: required when restenosis exceeded 50%. |
| Sim (11) | Peri-procedural and spontaneous | Clinically driven | Protocol-driven | Yes | MI: increase in cardiac biomarkers with or without symptoms; TLR: symptomatic revascularization with positive stress testing or clinical symptoms; TVR: restenosis identified through angiographic follow-up. |
| Jeger (12) | Peri-procedural and spontaneous | Clinically driven | Protocol-driven | Yes | MI: elevation of cardiac biomarkers (troponin/CK-MB); TLR: clinically driven based on symptoms or ischemic changes on imaging; TVR: protocol-driven when ≥50% stenosis was identified. |
| Tang (13) | Peri-procedural and spontaneous | Clinically driven | Protocol-driven | Yes | MI: confirmed by increased cardiac biomarkers with symptoms; TLR: clinically driven based on ischemic events or stress test findings; TVR: protocol-driven based on angiographic findings. |
Peri-procedural MI: Defined as a rise in cardiac biomarkers (CK-MB, troponin) during or immediately after the procedure.
Spontaneous MI: Includes myocardial infarction that occurs without procedural intervention, often related to underlying coronary disease progression.
Clinically driven TLR: Defined as revascularization procedures (either balloon angioplasty or stenting) required due to symptoms (e.g., chest pain) or evidence of ischemia (positive stress testing).
Protocol-driven TLR: Revascularization procedures driven by predefined criteria (e.g., restenosis ≥50%) observed during follow-up imaging.
Protocol-driven TVR: Revascularization of the entire target vessel driven by protocol, typically triggered by angiographic evidence of significant restenosis (≥50%).
Independent Adjudication: Indicates whether an independent committee or adjudicator was involved in the endpoint assessment process to ensure unbiased event reporting.