FIG. 4.

Time course of papilloma growth in rabbits vaccinated with the CRPV E1, E2, E6, and/or E7 gene. Panels are labeled according to the vaccine genes that were used. The graphs show the changes in mean papilloma volumes (in cubic millimeters) plotted on a natural logarithmic scale. The doses of CRPV used for challenge are represented as large closed circles (high dose) connected by continuous lines, large open circles (moderate dose) connected by continuous lines, and small closed circles connected by dashed lines (low dose). R, all papillomas at a given CRPV dose regressed.