Table 3.
Antimicrobial susceptibility profiles of 80 CRPA isolates.
| Antimicrobial | Overall R (%) | Overall I (%) | Overall S (%) | XDR R (%) | XDR I (%) | XDR S (%) | Non-XDR R (%) | Non-XDR I (%) | Non-XDR S (%) | Rate difference in R, % (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|
| AMK | 12.50 | 5.00 | 82.50 | 33.30 | 16.70 | 50.00 | 3.60 | 0.00 | 96.40 | 29.7 (10.2 to 49.2) |
| LVX | 26.30 | 20.00 | 53.70 | 58.30 | 37.50 | 4.20 | 12.50 | 12.50 | 75.00 | 45.8 (24.3 to 67.3) |
| TZP | 30.00 | 11.30 | 58.70 | 75.00 | 20.80 | 4.20 | 10.70 | 7.10 | 82.20 | 64.3 (45.2 to 83.4) |
| ATM | 37.50 | 22.50 | 40.00 | 70.80 | 8.40 | 20.80 | 23.20 | 28.60 | 48.20 | 47.6 (26.3 to 68.9) |
| CAZ | 25.00 | 12.50 | 62.50 | 70.80 | 20.80 | 8.40 | 5.40 | 8.90 | 85.70 | 65.4 (46.3 to 84.5) |
| FEP | 21.30 | 16.30 | 62.40 | 66.70 | 25.00 | 8.30 | 1.80 | 12.50 | 85.70 | 64.9 (45.7 to 84.1) |
| IPM | 83.70 | 16.30 | 0.00 | 91.70 | 8.30 | 0.00 | 80.40 | 19.60 | 0.00 | 11.3 (−3.9 to 26.5) |
| MEM | 68.70 | 31.30 | 0.00 | 91.70 | 8.30 | 0.00 | 58.90 | 41.10 | 0.00 | 32.8 (15.8 to 49.8) |
| TOB | 6.30 | 11.30 | 82.40 | 33.30 | 4.20 | 62.50 | 1.80 | 1.80 | 96.40 | 31.5 (12.3 to 50.7) |
Resistance to the agents listed contributes to the XDR classification under the Magiorakos criteria. Differences between XDR and non-XDR isolates are therefore definitional and are presented for description only; no measures of association or hypothesis tests are reported for these comparisons. Rate differences refer to category R and are given with Wald 95% confidence intervals. R, resistant; I, intermediate; S, susceptible; CI, confidence interval; CRPA, carbapenem-resistant Pseudomonas aeruginosa; XDR, extensively drug-resistant; AMK, amikacin; LVX, levofloxacin; TZP, piperacillin/tazobactam; ATM, aztreonam; CAZ, ceftazidime; FEP, cefepime; IPM, imipenem; MEM, meropenem; TOB, tobramycin.