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. 2026 Oct 5;16(46):58950–58967. doi: 10.1039/d6ra07323a

Table 2. Substituent patterns and α-amylase inhibitory activity (IC50) of additional oxadiazole–sulfonamide hybrids 11d–g derived from the scaffold previously discussed in the antimicrobial activity section.

Compound Substituent (R) α-Amylase IC50 (µM)
11d Indole 2.34
11e Indoline 6.23
11f 6-Nitro indoline 6.59
11g 1-Benzhydryl piperazine 7.15