Table 1.
Vaccine schedule for all strategies
| Strategy | Receipt of PrEP | Route of administration | Vaccine product | PrEP regimen | PEP regimen |
| 1 | PEP alone | ID | PCEC (1 mL/vial) |
– | 0.1 mL×2 sites, Day 0, 3, 7, 28 or 30 (TRC-ID, 2–2-2-0-2) |
| 2 | PEP alone | ID | CPRV/PVRV (0.5 mL/vial) |
– | 0.1 mL×2 sites Day 0, 3, 7, 28 or 30 (TRC-ID, 2-2-2-0-2) |
| 3 | PEP alone | IM | CPRV/PVRV (0.5 mL/vial) |
– | 0.5 mL Day 0, 3, 7, 14, 28 or 30 (ESSEN, 1-1-1-1-1) |
| 4 | PEP alone | IM | PCEC (1 mL/vial) |
– | 1 mL Day 0, 3, 7, 14, 28 or 30 (ESSEN, 1-1-1-1-1) |
| 5 | PrEP+PEP | ID | PCEC (1 mL/vial) |
0.1 mL×2 sites
|
0.1 mL×1 site Day 0 and 3 |
| 6 | PrEP+PEP | ID | CPRV/PVRV (0.5 mL/vial) |
0.1 mL×2 sites
|
0.1 mL×1 site Day 0 and 3 |
| 7 | PrEP+PEP | IM | CPRV/PVRV (0.5 mL/vial) |
0.5 mL Day 0 and 7 |
0.5 mL Day 0 and 3 |
| 8 | PrEP+PEP | IM | PCEC (1 mL/vial) |
1 mL Day 0 and 7 |
1 mL Day 0 and 3 |
CPRV, chromatographically purified Vero cell vaccine; ESSEN, standard intramuscular regimen; ID, intradermal; IM, intramuscular; PCEC, purified chick embryo cell vaccine; PEP, post-exposure prophylaxis; PrEP, pre-exposure prophylaxis; PVRV, purified Vero cell rabies vaccine; TRC-ID, modified Thai Red Cross-Intradermal.