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. Author manuscript; available in PMC: 2006 Feb 10.
Published in final edited form as: J Biol Chem. 2001 Aug 27;276(46):43361–43373. doi: 10.1074/jbc.M103614200

Fig. 11. Model of the GC regulation by GCAP1.

Fig. 11

In the presence of μm [Ca2+]free GCAP1 inhibits GC activity (left). It is still unclear, whether an extra-cellular (intradiscal) ligand regulates GC activity. Upon illumination, GCAP1 causes change in the GC, increasing the enzymatic activity of cGMP production (right). In this model, binding of Ca2+ to GCAP1 does not cause dimerization, whereas GC is a dimer.