Table 1. Crystallographic summary (Å, °, ų).

The texture index is calculated from the refined spherical harmonic coefficients; a value of 1.0 indicates a random sample, and larger values indicate increasing degrees on non-randomness. In the last column, the top numbers are calculated using the Mercury CSD-Materials/Search/Crystal Packing Similarity tool, and the bottom numbers are calculated using the Mercury Calculate/Mol­ecule Overlay tool.

Compound	space group	cell	Z/Z′	R wp	GOF	Restraints constraints	Texture index
Acoltremon	P212121	a = 9.320220 (15)	4/1	0.13518	3.59	53	1.034
		b = 11.391105 (27)				5
		c = 16.26284 (4)
		V = 1726.587 (5)
Atrasentan (lab data)	P212121	a = 8.0278 (13)	4/1	0.22433	2.82	97	2.482
		b = 17.682 (5)				0
		c = 21.363 (4)
		V = 3032.4 (14)
Bromfenac	P	a = 4.177042 (8)	4/2	0.07019	1.77	104	1.038
		b = 18.31136 (13)				8
		c = 20.31125 (17)
		α = 98.7657 (9)
		β = 92.06845 (21)
		γ = 90.41030 (4)
		V = 1534.281 (4)
Daprodustat	P	a = 6.53821 (9)	4/2	0.09997	1.32	146	1.035
		b = 13.76324 (18)				8
		c = 22.2158 (7)
		α = 88.981 (5)
		β = 83.8947 (17)
		γ = 88.8464 (4)
		V = 1987.15 (3)
Defactinib	P21/n	a = 17.37114 (27)	4/1	0.06628	1.64	93	1.043
		b = 5.16713 (6)				7
		c = 25.4639 (4)
		β = 97.7305 (8)
		V = 2264.84 (6)
Dordaviprone	P21/n	a = 7.00482 (8)	8/2	0.13208	3.21	166	1.025
		b = 31.19722 (18)				7
		c = 22.9596 (5)
		β = 97.4097 (12)
		V = 4975.49 (4)
Resmetirom	P	a = 11.3094 (23)	4/2	0.07746		158	1.549
		b = 15.158 (6)				11
		c = 16.570 (7)
		α = 67.405 (13)
		β = 74.425 (7)
		γ = 69.526 (7)
		V = 2427.2 (4)
Xanomeline tartrate	P212121	a = 7.49025 (19)	4/1	0.07819		67	1.086
		b = 7.50712 (10)				5
		c = 37.5187 (9)
		V = 2109.68 (9)