Table 2.
Comparison of biomarker levels between patients with AD and healthy controls.
| Biomarker | Healthy controls (n = 101) | Patients with AD (n = 181) | Z-value | P-value |
|---|---|---|---|---|
| Allergic/inflammatory markers | ||||
| Absolute EOS count (×10⁹/L) | 0.08 (0.045,0.155) | 0.32 (0.165,0.515) | −9.198 | <0.001 |
| EOS (%) | 1.50 (0.75,2.25) | 5.00 (2.60,8.60) | −9.343 | <0.001 |
| Total IgE (IU/mL) | Not tested | 91.450 (28.225,247) | - | - |
| Coagulation/fibrinolysis markers | ||||
| D-dimer (mg/L) | 0.22 (0.15,0.28) | 0.29 (0.195,0.585) | −4.763 | <0.001 |
| FDP (mg/L) | 1.20 (1.00,1.76) | 1.9 (1.31,2.75) | −6.019 | <0.001 |
| DFR | 0.073 (0.056,0.097) | 0.110 (0.077,0.223) | −6.284 | <0.001 |
| Systemic inflammation indices | ||||
| SII | 459.080 (313.247,611.396) | 521.994 (355.734,829.622) | −2.788 | 0.005 |
| NLR | 2.043 (1.549,2.472) | 2.220 (1.632,3.857) | −2.689 | 0.007 |
| MLR | 0.229 (0.175,0.292) | 0.316 (0.224,0.434) | −6.049 | <0.001 |
| PLR | 121.514 (100.371,159.460) | 143.386 (115.209,194.523) | −3.527 | <0.001 |
| SIRI | 0.743 (0.558,1.254) | 1.125 (0.665,1.972) | −4.157 | <0.001 |
Data are presented as median (IQR). EOS, eosinophils; FDP, fibrinogen degradation product; DFR, D-dimer-to-fibrinogen ratio; SII, systemic immune-inflammation index; PLR, platelet-to-lymphocyte ratio; NLR, neutrophil-to-lymphocyte ratio; MLR, monocyte-to-lymphocyte ratio; SIRI, systemic inflammatory response index; NA, not applicable.