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. 2025 Dec 23;100(2):927–934. doi: 10.1038/s41390-025-04551-7

Table 2.

Associations between GLP-1, GIP and Glucagon in boys and girls.

Variable GLP-1 z-score GIP z-score Glucagon z-score
Girls Boys P-value Girls Boys P-value Girls Boys P-value
Anthropometrics
 Height (cm) −0.006 (0.158) 0.002 (0.642) 0.193 −0.000 (0.884) 0.004 (0.351) 0.671 −0.001 (0.809) −0.000 (0.915) 0.764
[−0.016, 0.003] [−0.006, 0.010] [−0.013, 0.013] [−0.005, 0.013] [−0.012, 0.012] [−0.009, 0.008]
 Weight (kg) −0.008 (0.217) 0.004 (0.413) 0.125 0.004 (0.618) 0.008 (0.196) 0.684 −0.002 (0.823) 0.000 (0.976) 0.767
[−0.019, 0.002] [−0.006, 0.014] [−0.011, 0.019] [−0.004, 0.018] [−0.018, 0.011] [−0.015, 0.012]
 BMI z-score −0.101 (0.214) 0.023 (0.686) 0.165 0.01 (0.876) 0.088 (0.236) 0.469 −0.077 (0.374) 0.018 (0.777) 0.376
[−0.259, 0.058] [−0.101, 0.148] [−0.159, 0.177] [−0.154, 0.181] [−0.248, 0.093] [−0.106, 0.142]
 WC z-score −0.080 (0.339) −0.047 (0.573) 0.168 0.096 (0.198) 0.065 (0.479) 0.729 −0.021 (0.841) −0.027 (0.762) 0.956
[−0.246, 0.085] [−0.116, 0.210] [−0.182, 0.227] [−0.115, 0.249] [−0.225, 0.185] [−0.204, 0.149]
Lipids
 HDL z-score 0.095 (0.232) 0.02 (0.803) 0.488 0.046 (0.613) −0.047 (0.515) 0.413 0.057 (0.511) 0.08 (0.245) 0.853
[−0.06, 0.25] [−0.13, 0.17] [−0.1897, 0.095] [−0.188, 0.095] [−0.11, 0.228] [−0.053, 0.208]
 LDL z-score −0.006 (0.945) −0.079 (0.236) 0.492 0.046 (0.561) 0.016(0.820) 0.820 0.126 (0.134) 0.063 (0.334) 0.555
[−0.169, 0.158] [−0.218, 0.052] [−0.110, 0.201] [−0.121, 0.153] [−0.038, 0.291] [−0.063, 0.191]
 Triglycerides z-score −0.000 (0.990) 0.062 (0.338) 0.538 0.071 (0.489) 0.027 (0.740) 0.736 0.154 (0.052) 0.115 (0.061) 0.689
[−0.148, 0.149] [−0.064, 0.189] [−0.130, 0.272] [−0.132, 0.187] [−0.001, 0.309] [−0.005, 0.234]
 Total cholesterol z-score 0.059 (0.476) −0.068 (0.315) 0.235 0.070 (0.357) 0.009 (0.896) 0.554 0.175 (0.032) 0.103 (0.109) 0.493
[−0.010, 0.22] [−0.202, 0.065] [−0.07, 0.219] [−0.127, 0.146] [0.015, 0.335] [−0.022, 0.231]
Insulin sensitivity
 HOMA-IR 0.095 (0.346) 0.113 (0.023) 0.877 0.071 (0.602) 0.139 (0.168) 0.681 0.273 (0.013) −0.027 (0.765) 0.037
[−0.103, 0.294] [0.016, 0.210] [−0.195, 0.336] [−0.06, 0.339] [0.005, 0.491] [−0.203, 0.148]
 HOMA2 0.219 (0.322) 0.294 (0.021) 0.796 −0.179 (0.557) 0.313 (0.195) 0.731 0.613 (0.009) 0.015 (0.942) 0.067
[−0.215, 0.654] [0.045, 0.543] [−0.419, 0.779] [−0.159, 0.785] [0.149, 1.076] [−0.419, 0.451]

All variables were adjusted for BMI z-score, except BMI z-score, height and weight. Bold values highlight the significant results.