HCM prediction	Zhang et al. (2025) evidence	Consistency
Multidomain interventions produce multiplicative (synergistic) effects	Zhang et al. did not directly test interventions. However, they note that lifestyle factors (physical activity, MIND diet) are associated with DNAm and promote cognitive resilience.	Indirect support – The DNAm signature identified by Zhang et al. is modifiable by lifestyle factors, suggesting that interventions targeting multiple levels (epigenetic, metabolic, immune) could have synergistic effects. This aligns with HCM Prediction 2.