HCM prediction	Zhang et al. (2025) evidence	Consistency
Allostatic integrity moderates the effect of neuropathological burden	Zhang et al. (2025) did not directly measure amyloid/tau in all subjects. However, they observed that DNAm signatures predicted dementia independently of APOE4 and cognitive reserve, suggesting that the MRS captures variance beyond neuropathological pathways.	Indirect support – The independence of the MRS from genetic and reserve factors implies that allostatic integrity (reflected by DNAm) may moderate clinical expression, consistent with the dissociation between pathology and symptoms.