| HCM prediction | Zhang et al. (2025) evidence | Consistency |
|---|---|---|
| Allostatic integrity moderates the effect of neuropathological burden | The MRS remained significantly associated with progression after adjusting for years of education (a proxy for cognitive reserve) and MMSE score. | Supported – The epigenetic risk score added predictive value beyond cognitive reserve proxies, indicating that allostatic integrity (captured by DNAm) moderates or overrides reserve effects, exactly as predicted. |
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