FIG. 4.

The structure of the viral protomer. (A) The structure of viral protomer is shown as a ribbon diagram to highlight secondary structural elements. Blue, VP1; green, VP2; red, VP3. Two neighboring protomers within a pentamer are shown, and the two views are related by a 90° rotation about the vertical axis (applicable also to panel B). The locations of the amino acid changes seen in variants are indicated (as shown in the key). (B) The same views as in panel A are shown with the structures of ICAM-1 and the PVR overlaid. These coordinates were obtained from the low-resolution structures of these receptors in complex with human rhinovirus 16 and human rhinovirus 14 (20) and poliovirus (3, 16). The coordinates were superposed on the EV11-207 structure by superposition of the picornavirus proteins. Both panels were drawn with Molscript (21) and rendered with Raster3D (29).