FIG. 5.

Mapping of EV11-207M, -C, and -R amino acid changes onto the surface of EV11-207. (A) Space-filling model of the complete EV11-207 virion. The majority of residues are blue, with the depth of color relating to their distance from the center of the virion. Those residues that are altered in the variants are colored as in Fig. 4. As in Fig. 4B the overlaid structures of PVR and ICAM-1 are shown to indicate the range of interactions with the viral capsid made possible by different modes of canyon-binding receptors. A single SCR domain from factor H (2) is shown in gold so that the small size of an SCR domain compared to those of the immunoglobulin (Ig) domains contained in ICAM-1 (two Ig domains contained in each coordinate set) and PVR (three Ig domains in each coordinate set) may be judged. (B and C) The canyon-binding receptors are shown more closely with views from opposite sides shown in the two panels. All panels were drawn with Molscript (21) and rendered with Raster3D (29).