Table 2.

Case reports of suspected adverse reactions that had been subjected to further evaluation: two case reports were subjects of validation studies (from Medline search), although original case report was not cited

Drug	Adverse events	Nature of validation studies
Perindoprilw10	Hypotension, stroke	Several controlled trials showed lower incidence of hypotension with perindopril (2001, 2000, 1999). None of the trial reports cited this specific case report of severe hypotension with perindopril and instead chose to cite study data on perindopril from 1991.w71 This suggests that this particular case report had little impact in stimulating further research
Methimazole or carbimazolew11	Severe congenital malformations	Prospective controlled cohort study (2001)w72 suggested a possible link but was not statistically conclusive. Study cited other published case reports but not specific case of interest here. It seems that this particular case report was not key stimulus for validation study