TABLE 3.
Substitutions present in infectious sequencesa
| Amino acid | Substitution |
|---|---|
| N peptide | |
| S546 | 1C, 3K |
| Q551 | 1H |
| N553 | 10S, 3D |
| R557 | 1N 5K |
| E560 | 3Q, 2K |
| A561 | 1T |
| Q563 | 1H |
| H564 | 1E, 4K |
| L565 | 1T 4M |
| Q567 | 7K, 5R |
| T569 | 3S |
| V570 | 1I |
| K574 | 3R |
| Q577 | 4R |
| I580 | 17V, 5L |
| C peptide | |
| M629 | 2I, 10L, 3Q, 1K |
| E630 | 19Q |
| D632 | 22E |
| R633 | 1T, 13K, 1Q |
| E634 | 3Q |
| N636 | 1G, 14S, 14D, 1E |
| Y638 | 1V, 2I |
| T639 | 3S |
| S640 | 9G, 7D, 3N, 1E, 4Q, 2K |
| L641 | 1V, 8T, 7I, 1E, 2Q, |
| S644 | 1G, 4T, 3D, 5N, 5E, 1Q, 1K, 4R, 1A |
| L645 | 2E |
| I646 | 7L |
| E647 | 3Q, 1T |
| E648 | 1G, 2A, 2D, 1Q, 7K, 1V |
| S649 | 6A |
| N651 | 3V, 5T, 5I, 2K |
| Q653 | 1K |
| E654 | 1D |
| K655 | 1E, 5Q, 2R |
| Q658 | 8K |
| E659 | 12D, 3K |
a
Substitutions in bold are FCD compatible (minECO ≤ 5.0 kcal/mol) with a trimeric hairpin structure. The destabilizing (minECO > 5.0 kcal/mol) predicted substitutions are in lightface italic type.