Table 3.
Clinical Outcomes of Inpatient versus Outpatient Management for Severe Hyperkalemia without Concurrent Acute Conditions or Life-Threatening ECG Abnormalities: before and after Overlap Weighting.
| Setting | Participants, n | Events, n | Unweighted OR, 95% CI | Weighted OR, 95% CI | |
|---|---|---|---|---|---|
| All-cause mortality | Inpatient | 99 | 6 | 1 [reference] | 1 [reference] |
| Outpatient | 275 | 5 | 0.29 (0.09-0.96) | 1.39 (0.31-6.26) | |
| Hyperkalemia recurrence | Inpatient | 99 | 4 | 1 [reference] | 1 [reference] |
| Outpatient | 275 | 27 | 2.59 (0.88-7.59) | 4.82 (1.04-22.44) |
Notes: Weighted estimates were obtained using propensity score–based overlap weighting, adjusted for age, sex, body mass index, diabetes mellitus, heart failure, coronary artery disease, stroke, malignancy, visit pattern, do-not-resuscitate code, use of renin–angiotensin system inhibitors, mineralocorticoid receptor antagonists, beta-blockers, loop diuretics, bicarbonate, and potassium binders, as well as laboratory values at the time of hyperkalemia (potassium, creatinine, estimated glomerular filtration rate, white blood cell count, hemoglobin, and platelet), 3-month increase in potassium level, and creatinine ratio (hyperkalemia / 3 months prior). No deaths directly attributable to hyperkalemia were observed in either group.
CI: confidence interval; ECG: electrocardiographic; OR: odds ratio.