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. 2026 Aug 21;9(5):1263–1270. doi: 10.31662/jmaj.2026-0089

Table 3.

Clinical Outcomes of Inpatient versus Outpatient Management for Severe Hyperkalemia without Concurrent Acute Conditions or Life-Threatening ECG Abnormalities: before and after Overlap Weighting.

Setting Participants, n Events, n Unweighted OR, 95% CI Weighted OR, 95% CI
All-cause mortality Inpatient 99 6 1 [reference] 1 [reference]
Outpatient 275 5 0.29 (0.09-0.96) 1.39 (0.31-6.26)
Hyperkalemia recurrence Inpatient 99 4 1 [reference] 1 [reference]
Outpatient 275 27 2.59 (0.88-7.59) 4.82 (1.04-22.44)

Notes: Weighted estimates were obtained using propensity score–based overlap weighting, adjusted for age, sex, body mass index, diabetes mellitus, heart failure, coronary artery disease, stroke, malignancy, visit pattern, do-not-resuscitate code, use of renin–angiotensin system inhibitors, mineralocorticoid receptor antagonists, beta-blockers, loop diuretics, bicarbonate, and potassium binders, as well as laboratory values at the time of hyperkalemia (potassium, creatinine, estimated glomerular filtration rate, white blood cell count, hemoglobin, and platelet), 3-month increase in potassium level, and creatinine ratio (hyperkalemia / 3 months prior). No deaths directly attributable to hyperkalemia were observed in either group.

CI: confidence interval; ECG: electrocardiographic; OR: odds ratio.