Table 2.
Results of Univariate and Multivariate Analyses.
| Univariate analysis | Multivariate Cox proportional-hazards model analysis | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 95% CI | 95% CI | |||||||||
| χ2 | Hazard ratio | Lower | Upper | p-value | χ2 | Hazard ratio | Lower | Upper | p-value | |
| Age (years) | 62.5 | 1.044 | 1.032 | 1.057 | < 0.0001 | 18.1 | 1.031 | 1.016 | 1.047 | < 0.0001 |
| NYHA functional class | 153 | 2.476 | 2.189 | 2.772 | < 0.0001 | 39.4 | 1.754 | 1.486 | 2.058 | < 0.0001 |
| Hemoglobin level | 57.4 | 0.817 | 0.774 | 0.862 | < 0.0001 | 2.01 | 0.949 | 0.884 | 1.019 | 0.1143 |
| eGFR | 57.5 | 0.981 | 0.976 | 0.986 | < 0.0001 | 0.64 | 0.997 | 0.991 | 1.003 | 0.4244 |
| BNP | 32.4 | 1.000 | 1.000 | 1.001 | < 0.0001 | 5.11 | 1.000 | 1.000 | 1.001 | 0.0219 |
| ARNI | 12.8 | 0.243 | 0.075 | 0.573 | < 0.0001 | 0.35 | 0.694 | 0.157 | 2.120 | 0.5538 |
| SGLT inhibitors | 15.8 | 0.292 | 0.124 | 0.577 | < 0.0001 | 0.42 | 0.746 | 0.268 | 1.699 | 0.5129 |
| Septal E/e’ | 20.9 | 1.035 | 1.020 | 1.050 | < 0.0001 | 0.76 | 0.993 | 0.978 | 1.008 | 0.3879 |
| Serum cholinesterase | 128 | 0.991 | 0.989 | 0.992 | < 0.0001 | 17.1 | 0.995 | 0.992 | 0.997 | <0.0001 |
| MMSE | 161 | 0.868 | 0.852 | 0.885 | < 0.0001 | 4.71 | 0.966 | 0.938 | 0.996 | 0.0238 |
| Total FIM at follow-up | 215 | 0.997 | 0.974 | 0.980 | < 0.0001 | 25.3 | 0.987 | 0.982 | 0.992 | < 0.0001 |
ARNI: angiotensin receptor neprilysin inhibitor; CI: confidence interval; FIM: Functional Independence Measure; GFR: glomerular filtration rate; MMSE: Mini-Mental State Examination; NYHA: New York Heart Association; SGLT: sodium glucose cotransporter.