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. 2025 Jun 12;155(8):2497–2507. doi: 10.1016/j.tjnut.2025.06.007

FIGURE 3.

FIGURE 3

ZIP14 contributes to the regulation of insulin secretion by modulating the zinc pool within the ER/Golgi system. The figure is modified from [15]. (A) Colocalization of immunofluorescent staining for ER membrane (KDEL) and ZIP14 was performed in MIN6 cells. Red: ZIP14; green: KDEL. Arrows highlight the colocalization of ZIP14 and KDEL. Scale bar = 10 μm. (B) Quantification of ER membrane positive for ZIP14 and the level of secreted insulin in MIN6 cells with and without a cotreatment of glucose and KCl. (C) Depiction of the proposed model for the role of ZIP14 in insulin secretion. ER, endoplasmic reticulum; Glu, glucose; KCl, potassium chloride; KDEL, lysine (K), aspartic acid (D), glutamic acid (E), and leucine (L); MIN6, mouse insulinoma cell line.