Table 2.
Associations of Etiology with Rapid Correction in Hyponatremia.
| Crude | Model 1 | Model 2 | |
|---|---|---|---|
| Kidney losses | 1.22 (0.57-2.64) | 1.26 (0.58-2.75) | 1.10 (0.47-2.55) |
| Non-kidney losses | 3.08 (1.44-6.59) | 2.77 (1.27-6.02) | 3.25 (1.38-7.66) |
| SIAD | 1 [reference] | 1 [reference] | 1 [reference] |
| Adrenal insufficiency | 5.34 (2.44-11.7) | 4.45 (2.00-9.94) | 5.32 (2.29-12.4) |
| Low solute intake | 2.47 (1.44-4.22) | 2.44 (1.41-4.22) | 3.15 (1.73-5.76) |
| Polydipsia | 12.7 (6.56-24.7) | 10.5 (5.28-20.8) | 10.3 (4.81-22.0) |
| Heart failure * | - | - | - |
| Cirrhosis | 0.48 (0.11-2.09) | 0.33 (0.07-1.47) | 0.57 (0.12-2.67) |
| Kidney disease | 0.79 (0.10-6.28) | 0.75 (0.09-6.12) | 1.57 (0.19-12.9) |
Crude and adjusted odds ratios (with 95% confidence intervals) associated with rapid correction in patients with hyponatremia are shown. Model 1 accounts for age and sex. Model 2 accounts for age, sex, high-acuity or intensive care unit stay, hypertonic solution administration, and baseline serum sodium level.
Abbreviation: SIAD: syndrome of inappropriate antidiuresis.
*No incidence of overcorrection in hyponatremia due to heart failure.