Table 3.

Associations of Etiology with Slow Correction in Hyponatremia.

	Crude	Model 1	Model 2
Kidney losses	1.34 (0.81-2.21)	1.35 (0.82-2.24)	1.48 (0.86-2.55)
Non-kidney losses	0.23 (0.12-0.44)	0.24 (0.13-0.46)	0.19 (0.09-0.37)
SIAD	1 [reference]	1 [reference]	1 [reference]
Adrenal insufficiency	0.29 (0.14-0.60)	0.31 (0.15-0.64)	0.28 (0.13-0.60)
Low solute intake	0.37 (0.25-0.53)	0.38 (0.26-0.55)	0.28 (0.19-0.42)
Polydipsia	0.07 (0.03-0.16)	0.07 (0.03-0.18)	0.07 (0.03-0.18)
Heart failure	1.98 (1.00-3.93)	2.15 (1.08-4.29)	1.79 (0.84-3.83)
Cirrhosis	3.08 (1.33-7.13)	3.45 (1.47-8.11)	2.24 (0.92-5.49)
Kidney disease	1.02 (0.33-3.12)	1.03 (0.33-3.16)	0.63 (0.20-1.98)

Crude and adjusted odds ratios (with 95% confidence intervals) associated with slow correction in patients with hyponatremia are shown. Model 1 accounts for age and sex. Model 2 accounts for age, sex, high-acuity or intensive care unit stay, hypertonic solution administration, and baseline serum sodium level.

Abbreviation: SIAD: syndrome of inappropriate antidiuresis.