Table 3.
Adverse Events.
| CCVD− | p Value | CCVD+ | p Value | p Value CCVD− vs CCVD+ | |||||
|---|---|---|---|---|---|---|---|---|---|
| ENZ | ABI | ENZ | ABI | ||||||
| n | 75 | 67 | 14 | 22 | |||||
| Any grade | 51 (68) | 44 (66) | 0.8586 | 8 (57) | 16 (73) | 0.4715 | >0.9999 | ||
| CCVD-related | 6 (8) | 10 (15) | 0.2876 | 1 (7) | 2 (9) | 0.5193 | 0.7683 | ||
| Hypertension | 3 | 3 | 0 | 2 | |||||
| Edema | 1 | 4 | 0 | 0 | |||||
| Atrial fibrillation | 1 | 0 | 0 | 0 | |||||
| ST elevation in ECG | 1 | 0 | 0 | 0 | |||||
| Grade ≥3 | 9 (12) | 14 (21) | 0.1789 | 1 (7) | 5 (23) | 0.3705 | >0.9999 | ||
| CCVD-related | 1 (1) | 4 (6) | 0.1884 | 1 (7) | 0 | 0.3889 | >0.9999 | ||
| Hypertension | 0 | 2 | 0 | 0 | |||||
| Edema | 0 | 1 | 0 | 0 | |||||
| Acute myocardial infarction | 0 | 1 | 0 | 0 | |||||
| Arrhythmia | 1 | 0 | 0 | 0 | |||||
| Rupture of aortic aneurysm | 0 | 0 | 1 | 0 | |||||
Data are n (%).
Event counts represent the total number of events.
ABI: abiraterone plus prednisolone; CCVD: cardio-cerebrovascular disease; ECG: electrocardiogram; ENZ: enzalutamide.